Apolipoproteins and LDL Receptor Activity
نویسندگان
چکیده
منابع مشابه
ized-LDL receptor activity in macrophages
Platelet secretory products were shown to modulate the interaction between lipoproteins and their receptors on macrophages. Preincubation of macrophages for 2 h at 37°C with platelet conditioned medium (PCM), followed by its removal and a further 5-h incubation in the presence of oxidized-LDL (Ox-LDL), resulted in increased cellular degradation of Ox-LDL (34%), stimulation of cellular cholester...
متن کاملSiblings with normal LDL receptor activity and severe hypercholesterolemia.
We report about a brother and sister having clinical symptoms similar to those of homozygous familial hypercholesterolemia (FH) but surprisingly who have normal low density lipoprotein (LDL) receptor activities (M. Harada-Shiba et al, J Jpn Atheroscler Soc 1991; 19:227-242). The LDL receptor activities in the cultured fibroblasts of the patients were compared with those of FH heterozygotes and ...
متن کاملRetinal pigment epithelium possesses both LDL and scavenger receptor activity.
The lipid metabolism of photoreceptors depends in part on the retinal pigment epithelium (RPE). One aspect of cholesterol homeostasis in cultured bovine RPE was evaluated by measuring low-density lipoprotein (LDL) and scavenger receptor activity with [125I]-LDL and [125I]Ac-LDL, respectively. Incubation of RPE cells in the presence of increasing concentrations of LDL or Ac-LDL resulted in down-...
متن کاملRapid fluorometric assay of LDL receptor activity by DiI-labeled LDL.
DiI-LDL (3,3'-dioctadecylindocarbocyanine-low density lipoprotein) has been extensively used in morphological and microscopic studies of receptor-mediated metabolism of LDL in many cell lines. To date the use of this fluorescent probe in a quantitative assay of LDL receptor activity has not been widely used in studies with multiple samples due to the lack of a practical method for quantitativel...
متن کاملSecreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.
PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic processing of the PCSK9 zymogen in the endoplasmic reticulum results in a tightly associated complex between the prodomain and the catalytic domain...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1987
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.15.5_1145